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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Review Article
14.
Prostaglandins and its analogues : An approach for
treatment of anoestrus and to enhance breeding
efficiency - G B Dudhatra, S K Mody, H B Patel, C M Modi, A B
Chukewar, Avinash Kumar and M M Awale
Vet World. 2012; 5(6): 378-384
doi:
10.5455/vetworld.201 2.378-384
Abstract
Cloprostenol is a synthetic prostaglandin F2α
analogue. It is a FP (Prostaglandin F) receptor
agonist, which shows powerful luteolytic effects.
It also stimulates the contraction of uterine and
bronchial smooth muscle and produces
vasoconstriction in some vessels. Anoestrous may
be due to some conditions like abnormal pregnancy,
early pregnancy, pyometra, endometritis, retention
of placenta, maceration and mummification. So, get
rid of this conditions cloprostenol is widely
used. It has been now in vogue to administer PGF2α
or its analogue in early postpartum cows and
buffaloes in order to hasten early resumption of
cyclic ovarian activity and thereby to increase
the reproductive efficiency. To improve
reproductive efficiency, it is necessary to
inseminate cows early in the breeding season so
that, thereby achieving a more compact calving
season. Breeding efficiency is increased by means
of synchronization of estrus, conception rate and
pregnancy rate. Estrus synchronization can be
achieved by lysis of corpus luteum by
administration of prostaglandin (PGF2α) or its
synthetic analogue on 5-17 days of the estrus
cycle. The cows will return to estrus within 3-5
days. The effective therapeutic doses for
cloprostenol are 500 μg in cattle and 175 μg in
pigs. However, for R-cloprostenol, the recommended
doses are: 150 μg in cattle and 75 μg in pigs. In
both cases, it is administered by the
intramuscular route.
Keywords: Anoestrus,
Breeding efficiency, Cloprostenol, Reproduction.
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